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Prevention of oxytocin induced hypotension in caesarean section under spinal anaesthesia.

Prevention of oxytocin induced hypotension by co-administration of different doses of phenylephrine with oxytocin in lower segment caesarean section under spinal anaesthesia: A randomized comparative study - NA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018549
Enrollment
420
Registered
2019-04-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O748- Other complications of anesthesiaduring labor and delivery

Interventions

Intervention1: Comparison of Two Diferrent doses of Phneylephrine with Oxytocin: Comparison of 50 and 75 microgram doses of Phenylephrine with Oxytocin in LSCS in Spinal anesthesia. Control Interventi

Sponsors

Maharana Bhupal Government Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant female patients with singleton pregnancy, taken up for caesarean section under spinal anaesthesia for various indications (elective or semi-elective).

Exclusion criteria

Exclusion criteria: 1. Emergency indication of cesarean section (like antepartum hemorrhage, placenta previa, abruptio placentae, more than two previous LSCS, preeclampsia, fetal distress, obstructed labour, umbilical cord prolapse, hand prolapse, patient in labor pains). 2.Patients having associated systemic illness. 3.Contraindications for spinal anesthesia. 4.History of seizures, coma, neurological signs or symptoms(Eclampsia). 5.Patient refusal to participate in study. 6.Any allergy to local anaesthetic. 7. Obese (weight >100 Kg), short stature(height 8.Parturients who had a fall in BP >20% of basal mean arterial pressure (MAP) following spinal anaesthesia but before oxytocin infusion.

Design outcomes

Primary

MeasureTime frame
To assess the incidence of oxytocin induced hypotension during caesarean section under spinal anaesthesia in parturients by comparing the effects of co-administration of oxytocin with phenylephrine 50µg or 75µg.Timepoint: Every 2min after the SAB till baby extraction and up to 10 min after the administration of the test drug solution, then every 5 min till the end of surgery.—

Secondary

MeasureTime frame
1.Rescue vasopressor requirement. 2. Magnitude of hemodynamic changes. 3. Incidence of side effects.Timepoint: Every 2min after the SAB till baby extraction and up to 10 min after the administration of the test drug solution, then every 5 min till the end of surgery.—

Countries

India

Contacts

Public ContactDr Devendra Verma

RNT Medical College

devendra.anaes@yahoo.in9414289538

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026