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Comparison of general anaesthesia and local anesthesia on post-operative cognitive change in elderly patients undergoing neurosurgery

General Anaesthesia Vs Sedation- Cognitive Decline In The Elderly- A Randomised Controlled Trial In Patients With Chronic Subdural Hematoma (GAS-CDE) - GAS- CDE

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018544
Enrollment
250
Registered
2019-04-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G939- Disorder of brain, unspecified

Interventions

Intervention1: General Anesthesia: Patients will be randomised to two groups. Group G will receive general anesthesia The group G will receive General anaesthesia using an IV induction agent (propofol

Sponsors

Dr Smita V
Lead Sponsor
Dr Sandhya MS
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1.Elderly patients ( Age > 65 years) 2.ASA grade II & III ( American society of Anesthesiologists grading) 3. Presenting with Chronic SDH for burr hole evacuation

Exclusion criteria

Exclusion criteria: 1. GCS ( Glasgow Coma Scale Score) 2. Repeat surgery 3. Patients with weakness of dominant upper limb. 4. Patients who do not understand Malayalam or English 5. ASA Grade IV and above 6. h/o TIA or stroke 7. Parkinsonâ??s disease 8. h/o cognitive decline for >3 months 9. Patient refusal 10. Failure to undergo the screening test ( Mini Mental State Evaluation (MMSE 3)

Design outcomes

Primary

MeasureTime frame
Anaesthetic technique associated with cognitive dysfunctionTimepoint: 2nd POD, 3 months and 1 year after surgery

Secondary

MeasureTime frame
Anaesthetic technique associated with good functional outcomeTimepoint: 2nd POD, 3 months and 1 year after surgery;Hemodynamic and ventilatory parameters and depth of anaesthesia scores associated with cognitive dysfunction and functional outcomeTimepoint: 2nd POD, 3 months and 1 year after surgery

Countries

India

Contacts

Public ContactDr Smita V

Sree Chitra Tirunal Institute for Medical Sciences and Technology

smita_vimala@yahoo.com09447699245

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026