To compare the effect of Dexmedetomidine and Lignocaine on changes in heart rate and blood pressure while taking out the endotracheal tube at the end of surgery.

COMPARISON OF INTRAVENOUS DEXEMEDETOMIDINE AND INTRAVENOUS LIGNOCAINE IN ATTENUATION OF HAEMODYNAMIC AND AIRWAY RESPONSE DURING TRACHEAL EXTUBATION IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERY.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/04/018528

Enrollment

100

Registered

2019-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: K358- Other and unspecified acute appendicitis

Interventions

Intervention1: Dexmedetomidine: patients will receive single dose intravenous 0.5mcg/kg dexmedetomidine administered as bolus over 60 seconds prior to extubation . Control Intervention1: lignocaine: p

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society of Anaesthesiologists (ASA) physical status grade I and II. 2.Patients aged between 18 to 60 years. 3.Patients posted for laparoscopic surgery.

Exclusion criteria

Exclusion criteria: 1.Patients with uncontrolled systemic disorder like diabetes, hypertension, hepatic or renal impairment, severe airway disorder, seizure disorder, ischemic and or congestive cardiac diseases,coronary artery disease or recent MI. 2.Concomitant use of drugs like beta blockers,calcium channel blockers ,ARBs, ACE inhibitors, digoxin, alpha-2agonists, anticonvulsants or psychotropic medications. 3.Anticipated difficult intubation. 4.Patients with unstable hemodynamics. 5.Patients with known hypersensitivity or allergy to either dexmedetomedine and lignocaine(study drugs). 6.Unwilling patients.

Design outcomes

Primary

Measure	Time frame
HAEMODYNAMIC RESPONSETimepoint: immediately before extubation and at 1,3,5,10,15 minutes post extubation.	—

Secondary

Measure	Time frame
To study the hemodynamic effects of dexmedetomidine and lignocaine on the patient immediately before extubation and at 1,3,5,10,15 minutes post extubation. Timepoint: quality of extubation	—

Countries

India

Contacts

Public ContactAPARIMIT PANDEY

kalinga institute of medical sciences

das.saswati12@gmail.com7756094980

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026