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Importance of studying the changes in an enzyme for the metabolism of drug named azathioprine in dermatology patients

Clinical relevance of thiopurine methyl transferase genotype and phenotype testing for azathioprine in dermatology

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/04/018519
Enrollment
120
Registered
2019-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L989- Disorder of the skin and subcutaneous tissue, unspecified

Interventions

None listed

Sponsors

Indian Association of Dermatologists Venereologists and Leprologists
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Consenting patients who had previously received azathioprine or currently on it attending the dermatology OPD during the study period

Exclusion criteria

Exclusion criteria: Those who had received blood transfusions in the preceding 90-120 days will be excluded for enzyme activity studies

Design outcomes

Primary

MeasureTime frame
1.To estimate the frequency of variations in TPMT levels 2.To assess the impact of inherited variations of TPMT allele/levels on adverse effects and clinical response to azathioprine in dermatology. Timepoint: at the end of one year—

Secondary

MeasureTime frame
1.To estimate the frequency of TPMT genetic polymorphisms 2.To study the correlation between TPMT genetic polymorphisms and enzyme levels Timepoint: at the end of one year—

Countries

India

Contacts

Public ContactSivaranjini R

Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)

siva11rsamy@yahoo.com9994085511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026