Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified
Conditions
Interventions
None listed
Sponsors
Chest Research Foundation
Eligibility
Inclusion criteria
Inclusion criteria: Healthy non-smoker Be at least 40 years of age Provide written informed consent Never smoker and not exposed to biomass for >10 years No major abnormality on clinical examination Normal spirometry, FEV1/FVC >0.70 (or IOS 80-120% predicted if not able to perform Spirometry) FEF25-75 > 65% DLCO >= 80% predicted Body plethysmography TLC >= 80% predicted Healthy smoker Be at least 40 years of age Provide written informed consent Be smoking tobacco in the form of bidi or cigarettes for at least 10 pack years No major abnormality on clinical examination Normal spirometry, FEV1/FVC >0.70 (or IOS 80-120% predicted if not able to perform Spirometry) FEF25-75 > 65% DLCO >= 80% predicted Body plethysmography TLC >= 80% predicted Healthy Biomass user Be at least 40 years of age Provide written informed consent Be exposed to biomass for at least 10 fuel-years (women)/ 20 fuel-years (men) (exposure of 2hrs/day for 10 years) after adulthood No major abnormality on clinical examination Normal spirometry, FEV1/FVC >0.70 (or IOS 80-120% predicted if not able to perform Spirometry) FEF25-75 > 65% DLCO >= 80% predicted Body plethysmography TLC >= 80% predicted Tobacco smoking COPD Be at least 40 years of age Provide written informed consent Be smoking tobacco in the form or bidi or cigarettes for at least 10 pack-years Have a clinical diagnosis of COPD (GOLD stage I to III) and post-bronchodilator FEV1/FVC ratio 1500 % predicted if not able to perform Spirometry) DLCO Body plethysmography TLC Non-smoking COPD Be at least 40 years of age Provide written informed consent Be exposed to biomass for at least 10 fuel-years (women)/ 20 fuel-years (men) after adulthood Have a clinical diagnosis of COPD (GOLD stage I to III): post-bronchodilator FEV1/FVC ratio 1500 % predicted if not able to perform Spirometry)) DLCO Body plethysmography TLC Never smoker FEV1 reversibility
Exclusion criteria
Exclusion criteria: Subjects suffering from comorbidities such as diabetes. Very Severe COPD patients would be excluded as the process of sputum induction may worsen their condition History of lung condition other than COPD including respiratory infectious diseases like tuberculosis, asthma, interstitial lung disease, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of proteins modified by oxidative post translational modification in COPD patientsTimepoint: Not applicable as this is an observational study and does not involve an intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| NoneTimepoint: 1 | — |
Countries
India
Contacts
Public ContactAmit R Agarwal
Chest Research Foundation
Outcome results
None listed