Health Condition 1: A09- Infectious gastroenteritis and colitis, unspecified
Conditions
Interventions
Intervention1: GROUP B: Children will receive ringer lactate (RL) [Sodium-130
mmol/L, chloride-109 mmol/L, lactate-28 mmol/L, potassium-4 mmol/L, calcium-1.5 mmol/L]
as per the WHO protocol for dehydr
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age more than 1 months to less than 12 years. 2. Acute diarrhoea (less than 7 daysâ?? duration) 3. Severe Dehydration (according to WHO criteria) 4. Severe metabolic acidosis (pH less than 7.2 AND/OR bicarbonate less than 15 mEq/L, and PaCO2 less than40 torr) 5. Corrected Non-anion gap metabolic acidosis (Anion Gap:10-16) or If Anion gap is more than 16, but delta Anion Gap/ delta Bicarbonate ratio, less than 1.
Exclusion criteria
Exclusion criteria: 1. Chronic diarrhoea 2. Extra intestinal infection 3. Patient not requiring intravenous fluid therapy 4. Children with Renal tubular acidosis, Acute Kidney injury, Chronic renal disease, Diabetic ketoacidosis, Lactic acidosis, poisoning, In born error of metabolism etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time taken for resolution of metabolic acidosis, i.e., achieving a pH of 7.3 and/or bicarbonate of more than 15 mEq/L in the two groupsTimepoint: time taken for resolution of metabolic acidosis, i.e., achieving a pH of 7.3 and/or bicarbonate of more than 15 mEq/L in the two groups | — |
Secondary
| Measure | Time frame |
|---|---|
| I. Comparison of time taken for correction of dyselectrolytemias (sodium, potassium, and chloride), if present at admission. II. Comparison of occurrence of III. Comparison of pSOFA scores. IV. Comparison of Vasoactive Inotrope Score (VIS). V. Comparison of length of acute care area stay and total hospital stay. VI. Incidence of adverse events (Hypernatremia, AKI, MOF).Timepoint: Till patient discharge | — |
Countries
India
Contacts
Public ContactProf Arun Baranwal
PGIMER Chandigarh
Outcome results
None listed