Health Condition 1: O10-O16- Edema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: Furosemide: Furosemide 40 mg once a day will be given orally to women with postpartum hypertension for 7 days
Control Intervention1: Amlodipine: Amlodipine 5 mg once a day will be given
Sponsors
UCMS and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: In women diagnosed antenatally as preeclampsia/eclampsia/ gestational hypertension who within 48 hrs of delivery have blood pressure recording of systolic >= 150 mm Hg and/ or diastolic >= 100 mm Hg (2 recordings 4 hrs. apart) or systolic >= 160 mm Hg and/ or diastolic >= 110 mm Hg (single recording) Denovo hypertension diagnosed within 48 hrs. of delivery defined as blood pressure recording of systolic >= 150 mm Hg and/ or diastolic >= 100 mm Hg (2 recordings 4 hrs. apart) or a single recording of systolic >= 160 mm Hg and/ or diastolic >= 110 mm Hg
Exclusion criteria
Exclusion criteria: Women with chronic hypertension Preexisting hypokalemia Acute or Chronic renal disease S creatinine > 1.1mg/dl Preexisting diuretic use Oliguria Hemodynamic instability Collagen vascular disease Sickle cell disease Contraindication to furosemide Receiving MgSO4 therapy Received intravenous furosemide during ICU care Diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need to add another antihypertensive for blood pressure control,Frequency of very high blood pressure episodes, Control of blood pressure and time until blood pressure control in 7 days Timepoint: Need to add another antihypertensive for blood pressure control,Frequency of very high blood pressure episodes, Control of blood pressure and time until blood pressure control in 7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of use of antihypertensive agent for the treatment of hypertensive crisis, Length of hospital stay; Adverse effects: hypokalemia, polydipsia, headaches, muscle weakness, and gastrointestinal symptoms; Frequency of maternal complications: eclampsia, infection, pulmonary edema, shock and maternal death, Breastfeeding neonatal side-effects such as: bradycardia, hypotension,hypoglycemia. Timepoint: 7 days | — |
Countries
India
Contacts
Public ContactPALLAVI BEHL
U.C.M.S. and GTB Hospital
Outcome results
None listed