Health Condition 1: K720- Acute and subacute hepatic failure
Conditions
Interventions
Intervention1: Hemodiafiltration: Hemodiafiltration increases the clearence of the large toxins by large volume ultrafiltrtion. Ultrafiltration carries toxins through the membrane pores by fluid flow,
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria also has serum ammonia levels of greater than or equal to 150 micromoles per liter.
Exclusion criteria
Exclusion criteria: Age less than 18 years or more than 65 years. serum ammonia levels less than 150 micromoles per liter. Preexisting diagnosis or suspicion of chronic kidney disease. Preexisting diagnosis or suspicion of chronic liver disease. Preexisting diagnosis of bleeding diathesis. Pregnancy or Lactation. Presence of AKI stage 3 (as per KDIGO AKI staging). Presence of past diagnosis of malignancy. Anticipated need for dialysis within next 12 hours as judged by the treating team. Systolic blood pressure Requiring artificial ventilation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of subjects in either group who are alive at 30 days after enrollment.Timepoint: 30 days after enrollment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Percentage of subjects who develop new onset respiratory failure requiring mechanical ventilation. 2.Percentage of subjects who develop refractory shock. 3.Percentage of subjects who develop new onset major bleeding complications. 4.Percentage of subjects who develop new onset sepsis or any infectious complications. 5.Percentage of subjects in either group who are alive at 3,7 and 14 days after enrollment. 6.Time to mortality.Timepoint: At the time of enrollment. At days 3,7, 14 and 30 days after enrollment. | — |
Countries
India
Contacts
Public Contactvuppada siddhartha
Postgraduate Institute of Medical Education and Research (PGIMER)
Outcome results
None listed