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Comparing the effect of two different concentrations of the drug ropivacaine which causes numbness locally on application in the throat passage in patients undergoing thyroid surgery under general anaesthesia.

Comparison of topical ropivacaine 0.5% versus 0.75% and saline on intubation and extubation response in patients undergoing thyroid surgery under general anaesthesia: A randomized double-blind and placebo control study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018426
Enrollment
75
Registered
2019-04-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E00-E07- Disorders of thyroid gland

Interventions

Intervention1: Group R 0.5: Group R 0.5 will receive Laryngo-tracheal mucosal atomization with 0.5%ropivacaine. Intervention2: Group R 0.75: Group R 0.75 will receive Laryngo-tracheal mucosal atomizat

Sponsors

Government Medical College and Hospital Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists (ASA) physical status I /II. Patients undergoing thyroid elective surgery under GA.

Exclusion criteria

Exclusion criteria: 1.Morbid obesity (BMI > 35 kg.m-2). 2.Patients with severe cardiovascular, liver, and kidney diseases. 3.Patients with allergies to amide local anaesthetics. 4.Patients with increased risk of regurgitation and aspiration of gastric content. 5.Patients with difficult airway or history of maxillofacial and neck surgery. 6.Patients with history of chronic respiratory disease such as Chronic ObstructivePulmonary disease, chronic coughing or asthma, recent respiratory tract infection or smoking. 7.Pregnancy. The elimination criteria will be as follows: reoperation because of serious adverse events such as bleeding, anaesthesia time more than 3 h, and delayed extubation (more than 1 h without extubation) or transfer to the ICU with the tube.

Design outcomes

Primary

MeasureTime frame
To compare the haemodynamic responses during intubation and extubation as well as post operative incision pain and sore throat. Timepoint: Immediately after extubation.—

Secondary

MeasureTime frame
To compare the haemodynamic responses during intubation and extubation as well as post operative incision pain and sore throat. Timepoint: T0-Baseline, T1-before intubation, T2-immediately after intubation, T3-5 mins after intubation, T4-at the end of surgery, T5-immediately after extubation and T6- 5 mins after extubation. Patients will also be followed up to 6 hours after surgery to record the degree of sore throat and incision pain assessed by visual analogue scale (VAS)—

Countries

India

Contacts

Public ContactDrLakesh Anand

Government Medical College and Hospital, Chandigarh

lkanand11@gmail.com9646121522

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026