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To compare the effect of dexmedetomidine drug through two different routes of administration on suppressing intubation response.

A comparative study between Dexmedetomidine nebulisation and intravenous Dexmedetomidine on attenuation of sympathoadrenal response to laryngoscopy and intubation under general anaesthesia

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018416
Enrollment
80
Registered
2019-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Control Intervention1: Group DN - Dexmedetomidine nebulisation: Dexmedetomidine nebulisation (2mcg/kg) prepared in 3ml of normal saline given over 15 minutes, 30 minutes prior to intubation Control In

Sponsors

Dr Megha V
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who have given written informed consent 2. Patients with ASA grade I & II. 3. Patients aged 18-60 years. 4. Patients with BMI 19-28 kg/m2 5. Patients scheduled for elective surgery under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients not willing to give written informed consent. 2. Patients with history of allergy to dexmedetomidine.. 3. Patients with anticipated difficult mask ventilation/difficult intubation. 4. Patients with baseline heart rate 5. Patients with coronary heart disease, ischemic heart disease, heart blocks, diabetes mellitus. 6. Pregnant women/Breastfeeding mothers.

Design outcomes

Primary

MeasureTime frame
Dexmedetomidine nebulisation effectively attenuates pressor response to laryngoscopy and intubation when compared to dexmedetomidine given intravenously , efficacy parameter being hemodynamic parameters ( heart rate, systolic BP, diastolic BP, mean arterial pressures, SpO2Timepoint: Baseline Before drug After drug Before induction After induction Immediate after intubation 1 min after intubation 2 min after intubation 5 min after intubation 10 min after intubation—

Secondary

MeasureTime frame
dexmedetomidine nebulisation may have lesser side effects like bradycardia, hypotension, dizziness ,post operative sedation etc.Timepoint: Intra-operative Post-operative till 2 hours—

Countries

India

Contacts

Public ContactDr Megha V

Bangalore Medical College and Research Institute

drsats007@gmail.com9916207210

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026