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Comparative study of two different doses of buprenorphine with bupivacaine in spinal anesthesia in patients undergoing lower abdominal and lower limb surgeries

Comparative study of two different doses of intrathecal buprenorphine as adjuvant to 0.5% hyperbaric bupivacaine in subarachnoid block in patients undergoing lower abdominal and lower limb surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018414
Enrollment
54
Registered
2019-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 0.5% bupivacaine with Buprenorphine: 2.8 ml 0.5% Bupivacaine with 30 micrograms and 2.8ml 0.5% Bupivacaine with 45 micrograms of Buprenorphine Control Intervention1: 0.5% Bupivacaine wi

Sponsors

Abi Meenashy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective lower abdominal and lower limb surgeries in SMVMCH 2. Patients of ASA physical status 1 & 2 3. Patients of either sex 4. Age >18 years or

Exclusion criteria

Exclusion criteria: 1. Weight 90kg. 2. Body Mass Index >30. 3. Patients having chronic pain and on analgesic medications or with prior history of opioid and other substance abuse. 4. Patients having history of previous spine surgeries, deformity/congenital anomaly of the spine, bleeding disorders. 5. Patients with local site infection, allergy to the drugs that are tested or any other contraindications for regional anaesthesia. 6. Patients who cannot lie down/ non co-operative/ psychiatric illness. 7. Alcoholics. 8. Pregnant / Lactating women.

Design outcomes

Primary

MeasureTime frame
Post op analgesia Timepoint: Visual analogue scale at 0,10,15,30 and 60 minutes and then at every 30 minutes in post anaesthesia care unit during first 2 hours and then hourly till the next 12 hours in the post operative ward.Whenever VAS score reaches more than 4, rescue analgesia will be given in the form of intramuscular tramadol 50mg. Time to the first dose of tramadol will be recorded.—

Secondary

MeasureTime frame
Motor blockade Sensory blockade Timepoint: Motor block is assessed using Modified Bromage scale every 5 min until maximum motor block is achieved and then time of return of normal motor function will be noted.Sensory block will be determined using the pinprick method, dermatomal level will be assessed every 2 minutes from completion of injection until the assessed sensory level remained stable for four consecutive assessments. Testing will be conducted every 10 min thereafter until two-segment regression is noticed.—

Countries

India

Contacts

Public ContactAbi Meenashy

Sri Manakula Vinayagar Medical College And Hospital

lazarus.suneeth@gmail.com9894332543

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026