A clinical trial to study the association between reactive oxygen species and semen quality and the effect of vitamin C therapy in male infertility patients

Assessment of seminal plasma myeloperoxidase level (ROS)and the effect of vitamin C therapy on semen quality in infertile men - ROS

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/03/018303

Enrollment

258

Registered

2019-03-28

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N469- Male infertility, unspecified

Interventions

Intervention1: Tablet Vitamin C 500 mg : Drug for intervention group A: Tablet Vitamin C 500 mg OD for 3 months through oral route of administration. Every 6 weeks patients semen Patient recruitment

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 20-45 years with infertility 2. Patients with bilateral testies

Exclusion criteria

Exclusion criteria: 1. Patients on medications for infertility 2. Patients with known history of diabetes mellitus, hypertension, obesity, infection followed by infection, ischemic heart disease, metabolic syndrome and other chronic illness. 3. Patients with history of alcohol > then 60 units/week and smoking 4. Patients who are allergic to Vitamin C, orchitis TB and varicocele 5. Patient not willing to participate in the study

Design outcomes

Secondary

Measure	Time frame
This trial is to examine whether treatment of infertile males with an antioxidant formulation improves male fertility. The central hypothesis is that treatment of infertile males with antioxidants will improve sperm quality and function, resulting in higher fertilization rates and improved embryo development, leading to higher pregnancy and live birth rates. Timepoint: 3 months	—

Primary

Measure	Time frame
This study may anticipate the result of elevated seminal plasma Myeloperoxidase level (Reactive Oxygen Species) are linked to decreased sperm quality and vitamin C therapy is effective for reducing the oxidative stress (MPO) in seminal plasma which may improve the sperm quality in infertile men. Likely, this may optimize the fertility potential and maximize the chances of an assisted pregnancy rate.Timepoint: 3 months	—

Measure

Time frame

This study may anticipate the result of elevated seminal plasma Myeloperoxidase level (Reactive Oxygen Species) are linked to decreased sperm quality and vitamin C therapy is effective for reducing the oxidative stress (MPO) in seminal plasma which may improve the sperm quality in infertile men. Likely, this may optimize the fertility potential and maximize the chances of an assisted pregnancy rate.Timepoint: 3 months

—

Countries

India

Contacts

Public ContactRagesh

Sri Ramachandra Institute of Higher Education and Research

ganesh_radha@yahoo.in9841141310

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026