Health Condition 1: L86- Keratoderma in diseases classifiedelsewhere
Conditions
Interventions
Sponsors
Indian Association of Dermatologists Venereologists and Leprologists
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Non syndromic congenital ichthyosis patients regardless of age and sex. 2. Patients who can give valid consent
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Ichthyosis vulgaris 2. Those who cannot provide consent for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Mean difference in serum IL-17A and levels between patients and controls 2.Mean difference in Th17 cell levels 3.Mean difference in mRNA expression levels of IL-17 gene in peripheral blood mononuclear cells 4.Mean difference in tissue expression of IL-17 gene in skin biopsy samplesTimepoint: 1.Mean difference in serum IL-17A and levels between patients and controls - 2 years 2.Mean difference in Th17 cell levels - 2 years 3.Mean difference in mRNA expression levels of IL-17 gene in peripheral blood mononuclear cells- 2 years 4.Mean difference in tissue expression of IL-17 gene in skin biopsy samples - 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objective 1. Mean difference in serum IL-22 levels, a downstream IL between patients and controls 2. Mean difference in mRNA expression levels of IL-22 gene between patients and controls in peripheral blood mononuclear cells 3. Mean difference in tissue mRNA expression levels of IL-22 gene between patients and controls in skin biopsy samples Timepoint: AT THE END OF STUDY PERIOD | — |
Countries
India
Contacts
Public ContactRahul Mahajan
PGIMER Chandigarh
Outcome results
None listed