This is a clinico-radiographic study to compare and evaluate the efficacy of 1% Metformin (MF) gel in combination with Platelet Rich fibrin and Platelet Rich Fibrin (PRF) alone in the treatment of Class II furcation defects.

Comparative Evaluation of 1% Metformin (MF) gel plus Platelet Rich Fibrin and Platelet Rich Fibrin (PRF) alone in Treatment of Class II Furcation Defects: A Clinico-radiographic Study.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/03/018282

Enrollment

Registered

2019-03-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 1% Metformin gel plus Platelet Rich Fibrin: This is interventional study to evaluate the efficacy of 1% Metformin gel plus Platelet Rich Fibrin for treatment of Class II furcation defec

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with Stage III periodontitis as assessed by probing pocket depth (PPD)greater than equal to 6mm, interdental clinical attachment level (CAL) greater than equal to 5mm and Horizontal Probing depth (HPD) greater than equal to 2mm. 2. Patients with at least two Class II furcation defects in either maxillary or mandibular arch or interarch.

Exclusion criteria

Exclusion criteria: 1. Patients with history of systemic diseases, allergies or drug usage. 2. Patients who have undergone periodontal treatment in previous 6 months. 3. Pregnant or lactating women. 4. Smokers, tobacco chewers and patients with poor oral hygiene index (PI >1.5) will be excluded from the study. 5. In addition, teeth with furcation defects, non-vital teeth, carious teeth warranting restorations and mobility > grade II will also be excluded

Design outcomes

Primary

Measure	Time frame
Improvement in periodontal status i.e. e reduction in Probing Pocket Depth, Horizontal Probing Depth and gain in Clinical Attachment Level at baseline, 3 months and 6 months in both groups and improvement in radiographic bone fill in Class II furcation defects at baseline and 6 months in both groupsTimepoint: baseline, 3 months and 6 months	—

Secondary

Measure	Time frame
Improvement in Plaque and Gingival Indices at baseline, 3 and 6 months in both groups.Timepoint: baseline, 3 months and 6 months	—

Countries

India

Contacts

Public ContactDr Abhay P Kolte

Department of Periodontics and Implantology VSPM Dental College and Research Centre, Nagpur

drabhaypkolte@gmail.com9011071467

Outcome results