Health Condition 1: N979- Female infertility, unspecified Health Condition 2: N739- Female pelvic inflammatory disease, unspecified Health Condition 3: N839- Noninflammatory disorder of ovary,fallopian tube and broad ligament, unspecified Health Condition 4: K358- Other and unspecified acute appendicitis Health Condition 5: K37- Unspecified appendicitis
Conditions
Interventions
Control Intervention1: Group-A: In Group A- inj. Propofol infusion in the dose of 100-300 microgram/kg/min for maintainance of general anaesthesia (dose adjusted to maintain mean arterial BP within 20
Sponsors
Department of Anaesthesiology and Critical Care
Eligibility
Inclusion criteria
Inclusion criteria: Patients with ASA grade 1 and 2 and of age group 18 to 50 years with body weight 40 to 75 kg of either sex undergoing laparoscopic surgery in trendelenburg position under general anaesthesia and willing to give a written & informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with history of previous eye disease, ophthalmic surgery, baseline IOP >21 mmHg, difference in IOP of more than 8mm Hg between two eyes, diabetic retinopathy, cataract. 2. Patients who have received medication or surgery for previously diagnosed glaucoma or taking any medication which can alter IOP. 3. Patients with major systemic disease (morbid obesity, diabetes, hypertension). 4. Major organ dysfunction â?? respiratory / cardiac / neurological. 5. Patients with gastrointestinal, hepatic, renal, mental, or psychiatric illness. 6. History of medications like hypnotics, narcotic analgesics and antihypertensive. 7. History of known allergy to anaesthetic agents used in study. 8. Anticipated difficult intubation. 9. Deaf and dumb patient. 10. Patients requiring any drug other than our anaesthesia protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-operative and post-operative trends in intraocular pressure changes in mm Hg at T0-T5 time points in supine position.Timepoint: T0: before anaesthesia induction. T1: 5 minute after anaesthesia induction. T2: 5 minute after establishing CO2 pneumoperitonium. T3: 20 minute after establishing CO2 pneumoperitonium in trendelenburg position. T4: 5 minute after desufflation of CO2 pneumoperitonium. T5: 5 minute after trachial extubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| (a). heart rate, systolic BP, diastolic BP and mean arterial pressure at T0-T5 time points. (b). recovery characteristics as defined by Riker sedation agitation scale(RSAS) in OR; Ramsay sedation scale(RSS) and Modified aldrete score(MAS) in PACU at arrival, 5, 10 and 15 minutes. (c). peak inspiratory pressure and EtCO2 at T1-T5 time points. (d). incidence of adverse effects if any.Timepoint: T0: before anaesthesia induction. T1: 5 minute after anaesthesia induction. T2: 5 minute after establishing CO2 pneumoperitonium. T3: 20 minute after establishing CO2 pneumoperitonium in trendelenburg position. T4: 5 minute after desufflation of CO2 pneumoperitonium. T5: 5 minute after trachial extubation. | — |
Countries
India
Contacts
Public ContactDR U D SHARMA
DR. S.N. MEDICAL COLLEGE, JODHPUR
Outcome results
None listed