Health Condition 1: C069- Malignant neoplasm of mouth, unspecified Health Condition 2: null- patients with oral cavity cancer
Conditions
Interventions
None listed
Sponsors
RMLIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1. Treatment naive cases with early and locally advanced cancer of oral cavity, confirmed by biopsy ( histopathology will be gold standard for diagnosis). 2. Potential candidate for surgery 3. Performance status: ECOG 0-2 4. Patient consent to be part of study.
Exclusion criteria
Exclusion criteria: 1. Patients having a history of any other malignancy from which the patient has been disease-free for less than 2 years, with the exception of adequately treated basal or squamous cell carcinoma of skin. 2. Metastatic cancer of oral cavity. • Performance status: ECOG: >=3. • Presence of second malignancy. • Patients unwilling to take active treatment or to join the study. • A serious co-existing medical condition likely to interfere with lab results including a potentially serious infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proposed study is to assess the level of cfDNA in peripheral blood of early and locally advanced cases of oral cavity cancers initially before treatmentTimepoint: 2 years from the start of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate cfDNA as response assessment tool in the patients receiving induction chemotherapy To correlate cfDNA level with clinical & histo-pathological prognostic parameters. To correlate cfDNA with subsequent recurrence in a 18 months. Timepoint: 1.5 years | — |
Countries
India
Contacts
Public ContactDr akhlak Hussain
RMLIMS
Outcome results
None listed