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A study to find out how well pregabalin and gabapentin when given before surgery provides pain relief after surgery for lower abdominal surgeries done using spinal anaesthesia.

A prospective double blinded control study comparing the efficacy of Pregabalin and Gabapentin as a premedication in influencing postoperative analgesia for lower abdominal surgeries performed under subarachnoid block

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/03/018053
Enrollment
72
Registered
2019-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K35-K38- Diseases of appendix Health Condition 2: K40-K46- Hernia Health Condition 3: N80-N98- Noninflammatory disorders of female genital tract

Interventions

Intervention1: Pregabalin: 150mg Given per orally once 2 hours before spinal anaesthesia. Intervention2: Gabapentin: 600mg Given per orally once 2 hours before spinal anaesthesia. Control Intervention

Sponsors

Dr Pavithra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of both sexes consenting for lower abdominal surgeries under subarachnoid block BMI between18-25 kg/m2

Exclusion criteria

Exclusion criteria: ASA III and above physical status Pregnancy and Lactating mother Known psychiatric disorder Patients with cardiac disease or chronic kidney disease All neuropathies coagulopathies patient refusal for spinal anaesthesia Failed spinal inadequate level of block high spinal prolonged surgery Patient with allergic to the drug Patient who are already on Pregabalin or Gabapentin

Design outcomes

Primary

MeasureTime frame
To compare the intensity of postoperative pain in 3 groups by numeric pain intensity scale (NPIS) for 24 hours.Timepoint: postoperative period—

Secondary

MeasureTime frame
To assess the sedation score of the drugTimepoint: intraoperative and postoperative peroid;To compare the time interval between subarachnoid block and first rescue analgesicTimepoint: from intraoperative peroid till postoperative peroid;To evaluate the presence of any adverse effects of drug (diplopia, nausea, vomiting, diarrhoea, confusion, respiratory depression).Timepoint: intraoperative and postoperative peroid;To evaluate total dosage of rescue analgesics given in first 24 hours.Timepoint: postoperative period—

Countries

India

Contacts

Public ContactDr Pavithra

Shri Sathya Sai Medical College and Research Institute

vinodkrishnagopal@gmail.com9841557566

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026