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TO INVESTIGATE THE EFFECT OF BACTERIA PRESENT IN INTESTINE ON INFLAMMATION IN PATIENTS OF HIGH CHOLESTEROL WHO ARE TAKING STATIN DRUG (LIPID LOWERING DRUG) DRUG AS TREATMENT

TO INVESTIGATE THE INFLUENCE OF GUT MICROBIOTA COMPOSITION ON INFLAMMATORY MARKERS IN HYPERCHOLESTEROLEMIC SUBJECTS ON STATIN THERAPY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/03/018042
Enrollment
20
Registered
2019-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E780- Pure hypercholesterolemia

Interventions

Intervention1: ATORVASTATIN: For Group 1 we will administer 10 mg Atorvastatin then after six week will shift it on 40 mg atorvastatin. For Group 2 we will administer 40 mg Atorvastatin then after six

Sponsors

ARDU RUHS College of Health Sciences Jaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Confirmed cases of Hypercholesterolemia, defined as having the following: LDL >130 mg/dl, total cholesterol >200 mg/dl, HDL <40mg/dl

Exclusion criteria

Exclusion criteria: Use of lipid-lowering drugs 2. Patients of Acute and Chronic infections 3. Overt Nephropathy 4. Use of antibiotics, antifungals, antivirals and antiparasitics drugs

Design outcomes

Primary

MeasureTime frame
Changes in gut microbiome (Firmicutes and Bacteriodates) and fasting glucose, lipid profile and inflammatory markers (TNF-alpha and IL-6) at different doses of statin.Timepoint: 1. At 6 weeks of the study 2. At 12 weeks of the study—

Secondary

MeasureTime frame
To compare the effect of high and low dose of statin on Composition of gut microbiome (Firmicutes and Bacteriodates) and fasting glucose, lipid profile and inflammatory markers (TNF-alpha and IL-6) at different doses of statin.Timepoint: 1. At 6 weeks of the study 2. At 12 weeks of the study—

Countries

India

Contacts

Public ContactMs Sapna Jangir

RUHS-CMS, Jaipur

sonalisharma14@gmail.com9414314678

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026