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A study to compare the how good is dexmedetomidine and labetalol for providing reduced blood pressure during anaesthesia for surgeries of ear, nose and throat.

A randomized control trial to compare the efficacy of dexmedetomidine and labetalol for induced hypotensive anaesthesia in ear, nose and throat surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/03/018007
Enrollment
58
Registered
2019-03-08
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J399- Disease of upper respiratory tract, unspecified Health Condition 2: H952- Intraoperative hemorrhage and hematoma of ear and mastoid process complicating a procedure

Interventions

Intervention1: Dexmedetomidine: Loading infusion of 1mcg/kg over 10 minutes followed by maintenance infusion of 0.4mcg/kg/hr for producing controlled hypotension during general anaesthesia Interventio

Sponsors

Robin Sajan Chacko
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients of either sex undergoing elective ENT surgeries under general anaesthesia 2. American Society of Anaesthesiologists I or II 3. BMI between 18.5 and 24.9 kg/m2

Exclusion criteria

Exclusion criteria: 1. American Society of Anaesthesiologists III and above 2. Allergic to study drugs. 3. Asthmatic patients. 4. Patients having coagulopathy. 5. Patients with heart blocks. 6. Lactating mothers and pregnant patients. 7. Hepatic or renal abnormality. 8. Patients with congestive cardiac failure, bradycardia. 9. Hypertensive patients. 10. Patients using beta blockers.

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of dexmedetomidine and labetalol to induce controlled hypotension of 20-30% reduction in mean arterial pressure from the baseline.Timepoint: Intraoperative Period—

Secondary

MeasureTime frame
To compare recovery time between the study drugs.Timepoint: Postoperative period;To compare surgeonâ??s satisfaction of surgical field between the study drugs.Timepoint: Intraoperative period;To compare total blood loss occurring during surgery between the study drugs.Timepoint: Intraoperative period—

Countries

India

Contacts

Public ContactRobin Sajan Chacko

Shri Sathya Sai Medical College and Research Institute

vinodkrishnagopal@gmail.com984155756

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026