Health Condition 1: N201- Calculus of ureter
Conditions
Interventions
Intervention1: Group D: Group D - would receive intravenous dexmedetomidine 0.5 mcg/kg over 5 mins prior to induction
Control Intervention1: Group F: Group F - would receive intravenous fentanyl 1.5 m
Sponsors
Ankur Luthra
Eligibility
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists physical status I or II 2. Age of 20ââ?¬â??60 years 3. Either gender 4. Estimated operation time of ââ?°Â¤ 2 hours and anaesthesia time of ââ?°Â¤ 3 hours 5. Written informed consent to undergo the therapeutic regimen
Exclusion criteria
Exclusion criteria: 1. Renal dysfunction (serum creatinine > 1.2mg/dl) 2. Liver dysfunction (liver enzymes twice the normal range or higher) 3. History of chronic use of sedatives/ narcotics or analgesics/Beta blockers 4. BMI more than 30 kg/m2 or less than 15 kg/m2 5. Allergy to study medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EC 50 of propofol: The effective concentration of propofol will be recorded in all groups and will be used to calculate the EC50Timepoint: EC 50 of propofol: The effective concentration of propofol will be recorded in all groups just before insertion of I-gel airway and will be used to calculate the EC50 | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of sedation by RASS scaleTimepoint: Every 10 min from arrival in post anaesthesia care unit till discharge;Emergence timeTimepoint: At the end of surgery to eye opening;Haemodynamic indices including Systolic Blood Pressure, Diastolic blood pressure and Mean Arterial Pressure, Heart Rate, Oxygen saturationTimepoint: From preoperative to Discharge every 10 minutes;Intraoperative MAC requirementTimepoint: Every 10 minutes intraoperatiely;Occurrence of any adverse events and duration of stayTimepoint: In Post anaesthesia care unit postoperatively;Time to remove the airway deviceTimepoint: At the end of surgery;Total Propofol requirement for induction in each group Timepoint: After induction | — |
Countries
India
Contacts
Public ContactAnkur Luthra
Post Graduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed