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To look for a technique of anesthesia which is better for a children to decrease post operative complications caused due to inflammation mounted by used of heart lung machine

Inflammatory response of total intravenous anesthesia ( TIVA) and total volatile anesthesia in pediatric patients undergoing cardiac surgery : A randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/03/017985
Enrollment
50
Registered
2019-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Q211- Atrial septal defect Health Condition 2: Q213- Tetralogy of Fallot Health Condition 3: Q210- Ventricular septal defect

Interventions

Control Intervention1: Total intravenous anesthesia: Propofol and fentanyl with CLADS Control Intervention2: Total inhalation Anaesthesia: Induction with sevoflurane maintenance with isoflurane

Sponsors

PGI THESIS GRANT
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pediatric patients undergoing cardiac surgery for atrial septal defect, ventricular septal defect and tetralogy of fallot under cardiopulmonary bypass

Exclusion criteria

Exclusion criteria: Patients with multiple organ abnormalities in addition to cardiac defect, congenital syndromes, know genetic disorders, congenital infections associated with developmental delay, pre existing immunological disease, on steroids, on immunomodulatory drugs, malignancies and where consent is refused

Design outcomes

Primary

MeasureTime frame
To compare the inflammatory response in pediatric patients undergoing cardiac surgery for atrial septal defect, ventricular septal defect and tetralogy of fallot under cardiopulmonary bypass using total intravenous anaesthesia and total inhalationalal Anaesthesia.Timepoint: Before surgery, 24 hrs and 48 hrs post surgery—

Secondary

MeasureTime frame
Cognitive functions in children above 4Timepoint: Before surgery, 24 hrs and 48 hrs post surgery;Echocardiographic parametersTimepoint: Before surgery, 24 hrs and 48 hrs post surgery;Fluid balanceTimepoint: Before surgery, 24 hrs and 48 hrs post surgery;Oxygenation statusTimepoint: Before surgery, 24 hrs and 48 hrs post surgery;Renal function by RIFLE criteriaTimepoint: Before surgery, 24 hrs and 48 hrs post surgery;Vasoactive inotropic scoreTimepoint: Before surgery, 24 hrs and 48 hrs post surgery;Ventilation hoursTimepoint: Post operative ventilation hrs requirement—

Countries

India

Contacts

Public ContactBANASHREE MANDAL

POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH

banashreemandal@yahoo.co.in8146266102

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026