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Effectiveness of treatment in Parkinsons disease

Comparison of effectiveness of trihexyphenidyl and levodopa on motor symptoms in Parkinsonâ??s disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/03/017955
Enrollment
30
Registered
2019-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G20- Parkinsons disease

Interventions

Intervention1: Levodopa and trihexyphenidyl: Each patient will be given 2 drugs orally one after another (2 tab of L-Dopa 100 mg+ carbodopa 25mg and after 48 hour of wash period 2 tab of trihexyphenid

Sponsors

Department of Neurology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Parkinsonâ??s disease patients (fulfilling MDS clinical diagnostic criteria for PD) (who are currently taking or had taken trihexyphenidyl in the past)

Exclusion criteria

Exclusion criteria: 1. Patients with cognitive and behavioral disturbances. 2. Patients with history of urinary disturbances and benign hyperplasia of prostate. 3. Patients with angle closure glaucoma. 4. Patients with h/o cardiac illness 5. Patients with h/o postural hypotension. 6. Lack of consent.

Design outcomes

Primary

MeasureTime frame
Decrease in UPDRS motor scores after the treatmentTimepoint: Baseline, after 1 hour of levodopa tablets, after 48 hours, after 30 minutes, after 60 minutes, after 90 minutes, after 120 minutes—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactLulup Kumar Sahoo

NIMHANS

palpramod@hotmail.com9480829406

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026