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Comparison of intravenous vs intravenous plus nebulization of drug in trauma ICU patients.

Comparing safety and efficacy of aerosolized plus intravenous colistin and intravenous colistin alone for ETT culture positive multi drug resistant gram negative bacteria in trauma ICU.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/03/017941
Enrollment
100
Registered
2019-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B998- Other infectious disease

Interventions

Intervention1: Aerosolized plus intravenous colistin: Patients will be given intravenous plus aerosolized colistin (Loading dose of 9MIU of IV colistin over 30 min followed by 3MIU BD at 6a.m. and 6 p

Sponsors

Institute of Medical Sciences BHU
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ETT culture positive for MDR gram negative bacteria No associated co-morbidity

Exclusion criteria

Exclusion criteria: Patient suffering from COPD,Asthma,cystic fibrosis Patient suffering from renal,hepatic or cardiovascular disorder ETT culture positive for fungal infection ETT culture positive for gram positive bacterial infection

Design outcomes

Primary

MeasureTime frame
Microbiological cure of MDR gram negative bacteria in ETT culture and NephrotoxicityTimepoint: 0,5,10,14 days—

Secondary

MeasureTime frame
ICU mortalityTimepoint: 14 days;Length of ICU stayTimepoint: 14 days—

Countries

India

Contacts

Public ContactDr Ghanshyam Yadav
ghanshyambhu1976@gmail.com9838894169

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026