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Using markers of coronary artery disease to gain information about the disease

Correlation of biomarkers with plaque rupture versus erosion in Acute Coronary syndromes: Optical Coherence Tomography based study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/03/017933
Enrollment
140
Registered
2019-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I222- Subsequent non-ST elevation (NSTEMI) myocardial infarction

Interventions

None listed

Sponsors

ICMR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients presenting with Acute Coronary syndromes (STEMI, NSTEMI, Unstable Angina with >=10 minutes of angina or anginal equivalent consistent with unstable angina or myocardial infarction (MI) within 72 hours, with either elevated cardiac biomarkers (CK-MB or troponin) or ST-segment deviation of >1 mm in >=2 contiguous electrocardiographic leads) to EMOPD or OPD of the Department of Cardiology at GMCH-32, will be included.

Exclusion criteria

Exclusion criteria: 1. Cardiogenic shock. 2. Left Ventricular Failure (Killip Class 3 or 4). 3. Serum creatinine >=2.5 mg/dl. 4. Known allergy, hypersensitivity or contraindication to aspirin, heparin, or contrast. 5. Significant gastrointestinal or urinary bleed within the past 6 weeks, coagulopathy or bleeding diathesis. 6. Deranged LFTs like bilirubin >1.5mg/dl and enzymes 2 to 3 times elevated above upper limit of normal.

Design outcomes

Primary

MeasureTime frame
Association of biomarkers of inflammation with the type of plaque morphology.Timepoint: 30 days.

Secondary

MeasureTime frame
Correlation of the systemic biomarkers of inflammation and the coronary blood biomarkers of inflammation.Timepoint: 30 days.

Countries

India

Contacts

Public ContactDr Sreenivas Reddy

Govt Medical College and Hospital, Chandigarh

reddycardio2911@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026