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Effect of metformin in treatment of non-diabetic pulmonary tuberculosis patients

Metformin as an adjunct in treatment of pulmonary tuberculosis in non-diabetic patients:An open label study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/03/017926
Enrollment
150
Registered
2019-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A150- Tuberculosis of lung

Interventions

Intervention1: Tablet Metformin Hydrochloride: Tablet Metformin Hydrochloride 500 mg once daily per oral after dinner for two months alongwith standard Anti Tubercular Therapy. Control Intervention1:

Sponsors

Veer Surendra Sai Institute of Medical Sciences and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.New sputum positive cases 2.Non-diabetic (FBS 3.Not taking any other immunomodulator drugs.

Exclusion criteria

Exclusion criteria: 1. Immunocompromised states such as Chronic debilitating diseases, HIV-AIDS 2. Hb% 3. Any Drug resistant TB. 4. Impaired Liver or Renal function . 5. Respiratory Insufficiency/Hypoxia (peripheral oxygen saturation level 6. Pregnancy / Lactating mother.

Design outcomes

Primary

MeasureTime frame
1.Sputum conversion of new sputum positive non-diabetic pulmonary tuberculosis patients 2.Time taken for sputum conversionTimepoint: Every 15 days for a period of 2 months from initiation of therapy—

Secondary

MeasureTime frame
Effect of Metformin on: 1.Symptoms of Pulmonary TB- cough, fever, weight loss, breathlessness and fatigue. 2.Adverse effects in patients taking MET and ATT co-therapy Timepoint: Every 1 month after initiation of therapy.—

Countries

India

Contacts

Public ContactDr Sashi Bhusan Biswal

Veer Surendra Sai Institute of Medical Sciences and Research

pothal2002@yahoo.co.in9437238992

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026