A Comparison of two drugs (Clonidine and Enalapril)given to reduce increase in blood pressure during insertion of tracheal tube intubation and while making patient prone positioning during spine surgeries

A randomized double blinded comparative study of Intravenous Enalapril with Clonidine for stress attenuation during intubation and prone positioning in spine surgeries

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/03/017893

Enrollment

Registered

2019-03-01

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M512- Other thoracic, thoracolumbar andlumbosacral intervertebral disc displacement

Interventions

Intervention1: Injection Enalapril 1.25mg: Enalapril Dose - 1.25mg Route - Intravenous Time period - Over 10 minutes Frequency - Single injection Control Intervention1: Injection Clonidine 100microgra

Eligibility

Inclusion criteria

Inclusion criteria: Patients having problems in the spine (Lumbar and Thoracic) Age 18 to 70 years ASA 1 and 2 MPC 1 and 2 Willing to take part in the study

Exclusion criteria

Exclusion criteria: Patients who refuse the study Patients with known allergies to the study drugs Age >70 years Diabetic patients with autonomic dysfunction Hypertensive patients or those who on medications that influence blood pressure. ASA III & IV, Mallampatti class III & IV Emergency procedures

Design outcomes

Primary

Measure	Time frame
Heart rate and BP variability Timepoint: During tracheal intubation During postural change (Supine to prone positioning)	—

Secondary

Measure	Time frame
Intra operative haemodynamics Amount of intraoperative blood loss Surgeon’s opinion on the surgical field Aldrete score Renal profile Timepoint: Haemodynamics for the duration of surgery (every 5 minute ) till the end of surgery Blood loss assessed at the end of surgery ( 10 minutes after completing the case) Surgeons opinion at the end of surgery (10 minutes after completing the case) Aldrete score immediately after extubation Post operative renal profile	—

Measure

Time frame

Intra operative haemodynamics Amount of intraoperative blood loss Surgeon’s opinion on the surgical field Aldrete score Renal profile Timepoint: Haemodynamics for the duration of surgery (every 5 minute ) till the end of surgery Blood loss assessed at the end of surgery ( 10 minutes after completing the case) Surgeons opinion at the end of surgery (10 minutes after completing the case) Aldrete score immediately after extubation Post operative renal profile

—

Countries

India

Contacts

Public ContactDr Meshach M Das

SRM MCH RC CHENNAI

gayathrii.r@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026