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Comparison of side effect associated with amphotericin B deoxycholate infusion 24hrs vs 4hrs in trauma icu patients.

Comparing the safety and efficacy of Amphotericin B deoxycholate continuous infusion for 24 hrs vs 4 hrs in trauma ICU.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/02/017813
Enrollment
60
Registered
2019-02-25
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B379- Candidiasis, unspecified

Interventions

Intervention1: Amphotericin B (0.5 mg/kg in 5% dextrose 500 ml): One group will receive 4 hr infusion, other group will receive 24 hr infusion. Control Intervention1: NIL: NIL

Sponsors

Deptt of Anaesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 18 to 60 years with culture-based candida infection, having baseline Potassium, Creatinine, Liver Enzymes, and Urine Output within normal limits.

Exclusion criteria

Exclusion criteria: Patients not giving consent, Known case of allergy, hypersensitivity to AmpB deoxycholate, History of any systemic illness, Patients with deranged RFT and electrolyte imbalance, patient on any other antifungal treatment.

Design outcomes

Primary

MeasureTime frame
Blood cultureTimepoint: Day 21—

Secondary

MeasureTime frame
TLC, RFT, LFT, Electrolytes, Urine Output, CXRTimepoint: Day 0,3,6,9,14 and 21—

Countries

India

Contacts

Public ContactDr Monti Bori

IMS, BHU

ghanshyambhu1976@gmail.com5422369003

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026