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Preoperative pharmacological intervention for prevention of post operative sore throat and hoarseness.

Comparison of preoperative nebulised ketamine and intravenous dexamethasone used alone or in combination for the prevention of post operative sore throat and hoarseness.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/02/017804
Enrollment
90
Registered
2019-02-25
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R69- Illness, unspecified

Interventions

Intervention1: Intravenous Dexamethasone (0.1mg/kg) maximum up to 8mg single dose: Intravenous dexamethasone (0.1mg/kg) maximum 8mg single dose administered 15minutes preoperatively for the prevention

Sponsors

Lilavati Hospital and Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Age 18-75 yrs 2) Male and female patients undergoing elective surgery under general anaesthesia in supine position needing endotracheal intubation 3) American Society of Anesthesiologists (ASA) physical status I-II patients 4) Duration of surgery between 60 mins and 300 mins 5) Mallampatti classification I & II

Exclusion criteria

Exclusion criteria: 1)Recent history of respiratory tract infection or preoperative sore throat 2)More than one attempt at tracheal intubation 3)Pregnant and lactating females 4)Head and neck surgeries 5)Chronic steroid or NSAID(non steroidal anti inflammatory drugs) therapy 6)Known asthmatic or chronic obstructive pulmonary disease 7)Vulnerable subjects

Design outcomes

Primary

MeasureTime frame
Comparison of preoperative nebulised ketamine and intravenous dexamethasone used alone or in combination for the prevention of postoperative sore throat and hoarseness.Timepoint: To compare the incidence and severity of post perative sore throat and hoarseness graded on a four point scale at immediate recovery, 3hrs, 6hrs, 12hrs and 24hrs post operatively—

Secondary

MeasureTime frame
To study the incidence of adverse effects such as nausea, vomiting. Timepoint: Occurance of nausea and vomiting at immediate recovery, 3hrs, 6hrs, 12hrs and 24hrs post operatively .—

Countries

India

Contacts

Public ContactDsouza Blossom Benjamin

Lilavati Hospital and Research Centre

falgunishah26@yahoo.co.in9821258101

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026