To compare the level of a biochemical substance in the fluid around a screw after its placement and applying a force through a wire on it - An initial study

Comparing the levels of Biomarker post immediate and delayed Indirect loading of mini-screw implants-A preliminary study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/02/017791

Enrollment

Registered

2019-02-22

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Placement of mini-screw implants: Mini-screw implants will be placed in the bone through the gums and a force will be applied through them to pull the teeth . Total duration of the stud

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 15 to 25 years irrespective of the gender. 2. Subjects requiring bilateral first premolar extraction. 3. Positive informed consent. 4. No history of any systemic disease, hormonal imbalance, and anti-inflammatory drug intake in the near past. 5. Healthy periodontal tissue with generalized probing depth less than or equal to 3 mm.

Exclusion criteria

Exclusion criteria: 1. Patient with systemic conditions affecting bone metabolism and implant placement. 2. History of inflammatory drug administration in 6 months preceding the study. 3. Non-compliant patient with inability to maintain oral hygiene. 4. Not willing informed consent. 5. Patient with the habit of smoking or use of tobacco.

Design outcomes

Primary

Measure	Time frame
To estimate and compare the levels of IL-1Î² in the PMICF post immediate and delayed (after 3- week cooling period) loading in cases requiring canine retraction by indirect loading method.Timepoint: In 7 visits at 0th, 1st, 21st, 22nd, 43rd, 72nd and 120th day	—

Secondary

Measure	Time frame
1.To quantify the release of IL-1Î² in the PMICF . 2.To compare the levels of the biomarker. 3.To compare the results of biomarker quantification of immediate and delayed loading methods.Timepoint: In 7 visits at 0th, 1st, 21st, 22nd, 43rd, 72nd and 120th day	—

Countries

India

Contacts

Public ContactDr O P Kharbanda

Centre for Dental Education and Research, AIIMS

dr.opk15@gmail.com9899062144

Outcome results