Health Condition 1: C679- Malignant neoplasm of bladder, unspecified
Conditions
Interventions
Intervention1: Group D: Group D will recieve dexmedetomedine 0.4mcg/kg over 5 mins prior to induction followed by infusion at the rate of 0.4mcg/kg/hr till 10 mins prior to completion of surgery
Inter
Sponsors
Post Graduate Institute of Medical Education and research
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. American Society of Anesthesiologists physical status I or II 2. Age of 18â??65 years 3. Either gender 4. Estimated operation time of 5. Written informed consent to undergo the therapeutic regimen
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Renal dysfunction (serum creatinine > 1.2mg/dl) 2. Liver dysfunction (liver enzymes twice the normal range or higher) 3. History of chronic use of sedatives/ narcotics or analgesics 4. BMI more than 30 kg/m2 or less than 15 kg/m2 5. Allergy to study medication 6. Participants devoid of postoperative telephone access
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to emergenceTimepoint: Time to emergence | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives: 1. Predicted EC50 of propofol for induction 2. Total propofol requirment for induction 3. Intraoperative anaesthetic agent (MAC) requirement, 4. Postoperative pain scores (VNRS) 5. Perioperative analgesia requirements 6. PONV 7. Drowsiness (RASS score), 8. Duration of PACU stay, 9. Any adverse events. Timepoint: 120 minutes post intervention | — |
Countries
India
Contacts
Public ContactAnkur Luthra
Post Graduate Institute of Medical Education and research, Chandigarh
Outcome results
None listed