Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Yoga: 3 supervised sessions per week for 4 weeks
Control Intervention1: NOT APPLICABLE
SINGLE ARM TRIAL: NIL
Sponsors
National Institute of Mental Health and NeuroSciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Hoehn and Yahr stage 2 to 3 2. Duration of symptoms of PD of at least 3 years 3. On stable dosage of anti-PD medications for at least 6 weeks 4. Having motor fluctuations, either in the form of wearing off, dyskinesias or both, in spite of optimization of medical therapy for PD, based on the tolerability and affordability of various drugs
Exclusion criteria
Exclusion criteria: 1. Patients with severe cognitive deficits (Mini-mental status exam score 2. Patients who have undergone any type of surgery for Parkinsonâ??s disease 3. Patients who are unable to attend the Yoga sessions for the entire duration of study 4. Patients who have severe spondylotic disease or arthritis which may prevent them from undergoing Yoga sessions 5. Patients who are unable to perform the Yoga 6. Patients without a suitable caregiver
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study will test the hypothesis that, patients of PD with motor fluctuations receiving add-on 4 weeks Yoga therapy in addition to the stable dosage of medications for PD will have significant improvements of the following a. Duration of OFF state (assessed from patientâ??s daily diary) b. The motor part of UPDRS in both OFF and ON states c. The severity of dyskinesia in the ON stateTimepoint: The study will test the hypothesis that, patients of PD with motor fluctuations receiving add-on 4 weeks Yoga therapy in addition to the stable dosage of medications for PD will have significant improvements of the following a. Duration of OFF state (assessed from patientâ??s daily diary) b. The motor part of UPDRS in both OFF and ON states c. The severity of dyskinesia in the ON state | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improve the above non-motor problems 2. The serum levels of CRP, IGF-1 will decrease and BDNF will increase after Yoga 3. TMS will show changes in cortical excitability 4. Changes in the functional MRITimepoint: 8 weeks | — |
Countries
India
Contacts
Public ContactPooja Mailankody
National Institute of Mental Health and NeuroSciences
Outcome results
None listed