Health Condition 1: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention1: Curcuma longa: curcuma longa 400 mg capsules will be given for three times a day for 3 months to check the anti diabetic activity.
Control Intervention1: PLACEBO: maize starch will be u
Sponsors
Academic trial JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with type 2 diabetes mellitus diagnosed within the past 3 months to 10 years, on a stable dose of metformin and (or) sulfonylureas, for at least past 3 months 2. HbA1c <8%
Exclusion criteria
Exclusion criteria: 1. Liver dysfunction (AST, ALT > 2 times the upper limit of normal) 2. Renal dysfunction (GFR 3. Patient with concurrent illnesses like CAD(Coronary Artery Disease), CVA( cerebrovascular accidents), PVD(Peripheral Vascular Disease), CKD( Chronic Kidney Disease) 4. Pregnant women or lactating mother 5. women in the reproductive age group not practising contraceptive measures. 6. Patients who had participated in other trials in the past three months. 7. Those on other herbal medications. 8. Chronic alcoholics 9. Patients with any active infections including diabetic foot infection 10. History of allergy to any drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the change in glycemic status (HbA1C, fasting blood glucose, post prandial blood glucose) from baseline to end of treatment (3 months) between oral Curcuma longa and placebo in patients with type 2 diabetes mellitusTimepoint: 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| i. To compare the change in OGTT based indices (HOMA-IR, Matsuda index) of insulin sensitivity and resistance from baseline to end of treatment (3 months) between oral Curcuma longa and placebo in patients with type ii. to compare changes in Adiponectin and Malondialdehyde (MDA) levels, frequency of adverse drug reactions between two groupsTimepoint: 3 | — |
Countries
India
Contacts
Public ContactKIRUBAKARAN R
JIPMER
Outcome results
None listed