Health Condition 1: R69- Illness, unspecified
Conditions
Interventions
Intervention1: Drug will be given in Intradural spinal space: Patients will be divided in 2 groups of 50 patients each. Patients in Group B of 50 patients will receive 3.0 ml of Bupivacaine heavy 0.5%
Sponsors
Peoples College of Medical Sciences R C
Eligibility
Inclusion criteria
Inclusion criteria: Total 100 patients of ASA Grade I and II between the age group of 30 to 65 years of age undergoing surgery under general anaesthesia will be taken. Patients will be divided into 2 groups of 50 patients each.
Exclusion criteria
Exclusion criteria: Patient with known allergy to any of the drugs used in the study, with significant cardiac, respiratory, hepatic or renal dysfunction, an anticipated difficult airway, hypotension, history of seizure disorder, presence of primary and secondary steroid deficiency or on steroid medication, H/O egg allergy will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All patients will be pre-oxygenated for 3 minutes with 100% oxygen. Patients will be induced either with Inj. Etomidate (group E) or Inj. Propofol (group P). Appropriate size endotracheal tube will be inserted after giving Inj. Succinylcholine 1-1.5mg/kg. Maitenance will be done with Oxygen- Nitrous Oxide Isoflurane Vacuronium and controlled ventilation. Residual Neuromuscular block will be reversed with Neostigmine and Glycopyrolate.Timepoint: All patients will be monitored for vitals.These will be recorded at as baseline on arrival in O.T., at the time of induction,1 min post-induction,3 min post- induction,after 1 min of laryngoscopy,3 min post - intubation,Thereafter at 5-minute intervals for first 20 minutes, then every 15 minutes intra-operatively until the end of surgery,Vital signs will be recorded every 20 minutesin the Post Anaesthesia Care recovery room. | — |
Secondary
| Measure | Time frame |
|---|---|
| After completion of surgical procedure, reversal of residual neuromuscular blockage will be achieved with Inj. Neostigmine (40μg/kg) and Inj. Glycopyrrolate (6μg/kg) and patients will be extubated.Timepoint: Patients will be observed for 2 hours in recovery room for any post operative signs and symptoms like nausea, vomiting, hypotension, bradycardia, respiratory depression, agitation and arrhythmias etc. The treatment if required will be given. | — |
Countries
India
Contacts
Public ContactDr Kanhaiya Lal Kishnani
Peoples college of Medical Sciences & R C
Outcome results
None listed