Health Condition 1: O998- Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: Density gradient centrifugation: Left over ejaculate will be subjected to density gradient centrifugation. It is method of sperating the diferent types cells in the ejaculate based on i
Sponsors
Aswathi Cheredath
MNR research centre
Eligibility
Inclusion criteria
Inclusion criteria: Men attending the university infertility clinics for routine semen analysis Oocyte donors who donate oocytes in routine IVF treatment Patients undergoing single embryo transfer on the day 5 of the embryonic development Patients undergoing single embryo transfer on the day 5 of the embryonic development
Exclusion criteria
Exclusion criteria: normal couples
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| whether incorporation of basic knowledge of endogenous quality of gametes as well as spent media analysis like secretome and spent media along with the artificial inteligence will help us in identifying a biomarker of embryo implantation. So that we can we can use this biomarker from bench to bedside in order to maximize the ART outcomeTimepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| In vitro modulation of endometrial cells by embryonic secretome and its potential as a surrogate marker of the implantation competence of IVF embryos Timepoint: 1 year;To annotate the metabolomics signature of oocytes and its association with the functional ability Timepoint: 1 year;To understand the association between sperm metabolites, genetic integrity and functional competence of spermatozoa Timepoint: 1 year;To understand the embryo metabolites analysis using high sensitivity, high resolution, fast NMR Spectroscopy in combination with extended embryo culture and machine learning Timepoint: 1 year | — |
Countries
India
Contacts
Public ContactDr Satish Kumar Adiga
Manipal Accademy of Higher Education
Outcome results
None listed