Health Condition 1: -
Conditions
Interventions
Intervention1: rTMS: TMS is based on the principle of electromagnetic induction, in which an alternating electric current is passed through a stimulation coil, which is placed above the scalp. Another
Sponsors
Child neurology DivisionDepartment of AIIMSNew Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Children and adolescents of either sex aged 5 -18 years diagnosed with focal onset drug refractory epilepsy as per with ILAE 2017. Drug refractory epilepsy will be defined as = 1 seizure / week OR 4 seizures/month despite on = 2 appropriately chosen and optimally prescribed antiepileptic drugs. 1. Duration of epilepsy for atleast 1 year 2. Seizures of single semiology 3. Majority (75%) of Interictal epileptiform discharges(SWI) arising over a single epileptogenic focus on sleep EEG Parents/ guardians willing to follow the treatment protocol of daily sessions for 10 days in 2 week with Sunday off and hospital follow up at 6 week and 10 weeks of total study period
Exclusion criteria
Exclusion criteria: Hemispheric epilepsy syndromes such as Rasmeussen’s encephalitis Hemiconvulsion-hemiplegia epilepsy syndrome or Hemimegalancephaly. 2. Diagnosed epileptic encephalopathy other than focal ESES (Electrical status epilepticus in sleep) 3. Diagnosed progressive neurological disorder 4. Previous epilepsy surgery or vagal nerve stimulation insertion. 5. Patient waitlisted for epilepsy surgery within 6 months 6. Presence of Metallic implants anywhere in the body
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients who achieve 50% seizure reduction from baseline at 8 weeks after rTMS therapy Timepoint: Proportion of patients who achieve 50% seizure reduction from baseline at 8 weeks after rTMS therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Proportion of patients who achieve 50% reduction in SWI on sleep EEG from baseline at 8 weeks after rTMS therapy 2.Change in cortical excitability induced by rTMS thrapy in terms of pre and post therapy change in motor threshold (MT), short-interval intracortical inhibition (SICI) and long- interval intracortical inhibition (LICI) by single pulse TMS 3.Effect of rTMS on the behavioural profile (as per CBCL) and cognition (MISIC) Timepoint: 8 weeks from baseline | — |
Countries
India
Contacts
Public ContactDr Rahul Sinha
AIIMS,New Delhi
Outcome results
None listed