Health Condition 1: N049- Nephrotic syndrome with unspecified morphologic changes
Conditions
Interventions
Intervention1: Vitamin D receptor Activator (Calcitriol): 1. Oral administration of Tablet Calcitriol 1 ug once daily for 5 consecutive days to patients with nephrotic syndrome before undergoing renal
Sponsors
Post Graduate institute of Medical Education and Research Chandigarh India
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of either sex with Age between 18-65, undergoing renal biopsy for Evaluation of Nephrotic Syndrome 2. Healthy patients of either sex with Age between 18-65, posted for voluntary kidney donation surgery within a fortnight
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| APOL1 expression in glomerular parietal epithelial cells Timepoint: 1. In patients with Nephrotic syndrome: 5 days 2. In healthy voluntary kidney donors: 15 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. biochemical analysis before and after Vitamin D receptor agonist 2. Urine Protein Creatinine ratio before and after Vitamin D agonistTimepoint: 1. In patients with Nephrotic syndrome: 5 days 2. In Healthy voluntary controls: 15 days | — |
Countries
India
Contacts
Public ContactRaja Ramachandran
Post Graduate Institute of Medical Education & Research, Chandigarh, India
Outcome results
None listed