Health Condition 1: A279- Leptospirosis, unspecified
Conditions
Interventions
Intervention1: venipuncture:
Blood sample (5ml) will be collected aseptically by venipuncture method
Control Intervention1: NIL: Not applicable
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Objective 1: To compare the various diagnostic tools for accurate diagnosis of human leptospirosis in patients presenting with acute febrile illness. Objective 2: To study serovar-specific clinical characteristics, complications and prognosis of infections by the predominant serovars. Objective 3: Molecular characterization of Leptospira by Multilocus sequence typing (MLST). Patients of both gender and >18 years of age presenting to the Kasturba Hospital, Manipal and diagnosed with Acute febrile illness (AFI) will be included in this study. Fever of Objective 4: Sero-epidemiological study of human leptospirosis amongst high-risk population (farmers) of Udupi District. Healthy farmers with no history of fever and antibiotic therapy in the previous two weeks and >18 years of age of both the gender will be included in the study.
Exclusion criteria
Exclusion criteria: Objective 1: To compare the various diagnostic tools for accurate diagnosis of human leptospirosis in patients presenting with acute febrile illness. Objective 2: To study serovar-specific clinical characteristics, complications and prognosis of infections by the predominant serovars. Objective 3: Molecular characterization of Leptospira by Multilocus sequence typing (MLST). Cases known to have confirmed alternate diagnosis (typhoid, malaria, brucellosis, scrub typhus and dengue) and of Objective 4: Sero-epidemiological study of human leptospirosis amongst high-risk population (farmers) of Udupi District. Farmers having chronic illness of chronic kidney disease, chronic liver disease and diabetes mellitus; history of fever in the previous two weeks; those who have received any antibiotic therapy in the previous two weeks and those of <18 years of age will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The study will help in generation of data which will help to choose appropriate diagnostic test in different phases of leptospirosis. 2.The distribution of various genomospecies/serovars of Leptospira in our setting can be obtained. Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Correlation between the various serovars and clinical presentation can be studied. 2.Knowledge of locally prevalent serovars causing leptospirosis would enable to formulate strategies for public health interventions in future. Timepoint: 1 1 | — |
Countries
India
Contacts
Public ContactRAVI KUMAR T N
Kasturba Medical College,Manipal
Outcome results
None listed