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Effect of alpha lipoic acid on reactive oxygen species levels after gum surgery in patients with diabetes and gum disease.

EFFECT OF ALPHA LIPOIC ACID ON SUPEROXIDE DISMUTASE LEVELS AFTER SURGICAL PERIODONTAL THERAPY IN PATIENTS WITH DIABETES AND CHRONIC PERIODONTITIS: A RANDOMIZED CLINICAL TRIAL - EALASODSPTDCP

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/01/017331
Enrollment
24
Registered
2019-01-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Periodontal Flap Surgery: 12 subjects will undergo Surgical periodontal therapy (open flap debridement) with administration of alpha lipoic acid 300mg 3 times a day for 3 months. Contr

Sponsors

Panineeya Institute of Dental Sciences and Research Centre
Lead Sponsor
Mohans Diabetic Centre
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 35 to 60 years. Patients with well-controlled Type II Diabetes (HbA1C levels 6 â?? 7%) Patients with Chronic periodontitis (Having minimum of 15 teeth, with bleeding on probing, Probing pocket depthï?³ 5mm, and Clinical attachment loss ï?³ 2mm and gingival recession).

Exclusion criteria

Exclusion criteria: Pregnant or lactating women. Patients using antibiotics from past 6 months Patients taking anti-inflammatory drugs. Smokers Systemically comprised patients (Other than diabetes)

Design outcomes

Primary

MeasureTime frame
Serum Superoxide Dismutase LevelsTimepoint: Baseline 3months and 6months—

Secondary

MeasureTime frame
Clinical parameters like Gingival Bleeding Index, Probing Pocket depth, Clinical attachment loss and gingival recessionTimepoint: Baseline 3months and 6months—

Countries

India

Contacts

Public ContactDrGChaitanya

Panineeya Institute Of Dental Sciences and Research Centre.

rekhasarat2304@gmail.com09885160094

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026