Health Condition 1: F329- Major depressive disorder, singleepisode, unspecified
Conditions
Interventions
Intervention1: Tablet Vilazodone OD orally.: Drug will be started at a dose of 10mg,dose will be increased every week by 10mg(max upto 40 mg)if inadequate response is obtained.
Control Intervention1:
Sponsors
Dr Ankushe rohini
Dr VSDeshmukh
Eligibility
Inclusion criteria
Inclusion criteria: 1)Patients of either sex with age between 18 to 65 years. 2)Newly diagnosed MDD patients meeting DSM- 5 criteria for depression. 3)Patient who give written informed consent.
Exclusion criteria
Exclusion criteria: 1)Pregnant or nursing women. 2)Patients with high risk of suicidal tendency or previous suicide attempt within 6 months. 3)Patients with bipolar disorder, drug abuse or dependency, post traumatic stress disorder, obsessive â?? compulsive disorder. 4)Patients with previous depression resistant to antidepressants and those who had taken treatment with electroconvulsive therapy in previous 3 months or formal psychotherapy within 1 month. 5)Patients on other antidepressants. 6)Patients with neurological disorders (dementia, seizures, stroke), obesity with functional impairment, serious or unstable organic disorder (neoplasia, cardiovascular, pulmonary,uncontrolled type 1 or 2 diabetes). 7)Any other medical disorder which is confounding our inclusion diagnosis. 8)Patients with drug intake for psychosis or anxiety. 9)Any history of allergy to the drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome name : 1)Hamilton Depression Rating Scale.(used for sample size calculation. ) 2)Udvalg for Kliniske Undersolgelser(UKU)scale. 3)Blood investigations[CBC, SGOT,SGPT ,serum bilirubin(direct and indirect) serum creatinine & serum urea.]Timepoint: Time point : 12 weeks . | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome name: 1)Hamilton Anxiety Rating Scale(HAM-A). 2)Montgomery-Asberg Depression Rating Scale(MADRS). 3)Clinical Global Impression Scale(CGI)involving, Clinical Global Impression-Severity(CGI-S) and Clinical Global Impression-Improvement(CGI-I)score.Timepoint: Time point: 12 weeks | — |
Countries
India
Contacts
Public ContactDr Ankushe Rohini
Government Medical College, Latur.
Outcome results
None listed