To compare the effects of local application of hyaluronic acid gel and chlorhexidine gel in treatment of patients with gum disease.

Comparative evaluation of the therapeutic effect of Hyaluronic acid gel (HA) with chlorhexidine gel used as a local drug delivery agent in patients with chronic periodontitis - A randomized controlled clinical trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/01/017269

Enrollment

Registered

2019-01-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B998- Other infectious disease

Interventions

Intervention1: Hyaluronic acid gel (0.2%, 0.8%, 1%): Hyaluronic acid is a naturally occurring high molecular weight non sulphated glycosaminoglycan which forms the major and critical component of conn

Eligibility

Inclusion criteria

Inclusion criteria: 1. patients with minimum of 18 natural teeth in mouth 2. chronic periodontitis patients with probing pocket depth >/ 5mm in minimum of three teeth per quadrant bilaterally in the maxillary arch.

Exclusion criteria

Exclusion criteria: 1.use of local or systemic antimicrobial agents 6 months prior to study. 2. previous periodontal therapy during last 6 months. 3.pregnancy 4. smokers 5.regular users of mouth wash. 6.chronic alcoholics 6.patients using vitamin supplements, anti inflammatory agents in past 3 months.

Design outcomes

Primary

Measure	Time frame
1. clinical parameters between the different concentrations of hyaluronic acid gel are compared at 3 months.Timepoint: 1. clinical parameters between the different concentrations of hyaluronic acid gel are compared at 3 months.	—

Secondary

Measure	Time frame
to evaluate drug release of hyaluronic acid gel released from gingival crevicular fluid after the treatment.Timepoint: 4 hours, 2 weeks.	—

Countries

India

Contacts

Public ContactJaahnavi Lanka

MAHE

santhosh.kumar@manipal.edu9741968550

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026