COMPARISON OF TWO DOSES OF OF A PAIN KILLER (NALBUPHINE) AS AN ADDITIVE TO LOCAL ANESTHETIC IN SPINAL ANESTHESIA.

COMPARISON OF 0.4 MG VERSUS 0.6 MG INTRATHECAL NALBUPHINE AS AN ADJUVANT TO HYPERBARIC BUPIVACAINE 0.5% IN LOWER ABDOMEN AND LOWER LIMB SURGERIES

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/01/017240

Enrollment

120

Registered

2019-01-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group A: This group of patients will receive 0.4 mg of Nalbuphine as an adjuvant to 3 ml of 0.5% Bupivacaine plus 0.2 ml of normal saline intrathecally Control Intervention1: Group B:

Eligibility

Inclusion criteria

Inclusion criteria: All ASA 1 and 2 patients undergoing elective lower abdominal and lower limb surgeries under spinal anaesthesia

Exclusion criteria

Exclusion criteria: Infection at the site of injection ASA 3 and 4 Patients Hypersensitivity to Local Anaesthetics Increased intracranial pressure Coagulation disorders and other bleeding diathesis Pregnant Patients Patient with Infection at the site of injection ASA 3 and 4 Patients Hypersensitivity to Local Anaesthetics Increased intracranial pressure Coagulation disorders and other bleeding diathesis Pregnant Patients Patient with poorly controlled hypertension Patients with spine abnormalities and demyelinating lesions Patients with psychiatric illnesses Patients with significant hypotension, severe aortic/mitral stenosis Uncooperative Patients

Design outcomes

Primary

Measure	Time frame
Onset and duration of Motor and sensory BlockadeTimepoint: Duration of sensory Blockade assessed every hourly until the first rescue analgesia is required. Duration of motor blockade assessed by modified Bromage scale , assessed till the patient will be able to perform partial knee bend(modified bromage 6)	—

Secondary

Measure	Time frame
Nausea, vomiting, pruritusTimepoint: if any will be taken into record for the first 24 hours	—

Countries

India

Contacts

Public ContactRaghuraman M S

SRI VENKATESHWAARA MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE

drraghuram70@gmail.com9486837256

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026