Health Condition 1: F10-F19- Mental and behavioral disorders due to psychoactive substance use
Conditions
Interventions
Intervention1: Yoga: one hour generic yoga intervention 5 days a week for 3 months. First 2 weeks of supervised sessions followed by home practice.
Control Intervention1: Treadmill walk: 1 hour of bri
Sponsors
Department of Science and Technology SATYAM Scheme
Eligibility
Inclusion criteria
Inclusion criteria: They will be recruited from Centre for Addiction Medicine, National Institute of Mental Health And Neurosciences (NIMHANS) from the outpatient department and inpatient department. 3. Diagnosed with Opioid dependence syndrome (prescription and street Opioids) as per ICD-10 4. Patients stabilized by medications for withdrawal symptoms 5. Willingness to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. H/o or current medical illness that may significantly influence CNS function or structure 2. Patients with intractable pain due to other diseases 3. Patients on prescribed opioids for pain of other medical conditions 4. General impaired intellectual functioning (Mini-Mental Status Exam, MMSE below24 ) 5. Contraindication to MRI like metal implants or paramagnetic objects within the body or claustrophobia 6. Past history of head injury 7. Concomitant severe medical conditions 8. Those with co-morbid alcohol/BZD/Cannabis/Multiple substance dependence except nicotine 9. H/o receiving specific Yoga practice for Opioid dependence in the past 10. Pregnancy or post-partum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma endorphin levels and Buprenorphine dosage requirementTimepoint: At 0, immediate after 1st yoga session, after 2 weeks and at 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Various psychometric tests which assess psychological state, craving, withdrawal symptoms, quality of life, suicidality etc. Biological Assessments Other lab assessments: Complete blood count; liver function (AST, ALT, LDH, bilirubin); fMRI acquisition and analysis: Relapse rate and number of hospitalizations will also be assessed Timepoint: At 0, immediate after 1st yoga session, after 2 weeks and at 3 months | — |
Countries
India
Contacts
Public ContactDr Prateek Varshney
NIMHANS, Bengaluru, India
Outcome results
None listed