Health Condition 1: J708- Respiratory conditions due to other specified external agents
Conditions
Interventions
None listed
Sponsors
Glaxo Smith Kline
Eligibility
Inclusion criteria
Inclusion criteria: 1.Male or female at least 40 years old 2.Capable of giving written informed consent 3.Have a prior diagnosis of COPD documented in the medical record 4. Have COPD diagnosis confirmed by post-bronchodilator spirometry test at enrolment 5. Have moderate-severe airflow limitation defined as a forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) less than 0.7 and FEV1 less than 80% predicted on post-bronchodilator spirometry at enrolment
Exclusion criteria
Exclusion criteria: 1. Onset of COPD symptoms before 30 years of age 2. Experienced an acute exacerbation of COPD (defined as an acute worsening of symptoms that result in treatment with an antibiotic or oral steroid) within the four weeks prior to, or on the date of, enrolment 3. Have diagnosed asthma over the past 12 months or have experienced asthma symptoms with a clinical history suggestive of asthma in the past 12 months 4. Have cystic fibrosis, pulmonary fibrosis or bronchiectasis documented in the medical record 5. Have active tuberculosis or are taking medication for tuberculosis 6. Have had pulmonary resection surgery 7. Are pregnant (women of childbearing potential with positive urine pregnancy test will be excluded)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome will include circulating blood eosinophil count; for each patient two estimates will be derived: cells per μL, and as % total white blood cell count (WCC).Timepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Primary outcome will include circulating blood eosinophil count; for each patient two estimates will be derived: cells per μL, and as % total white blood cell count (WCC).Timepoint: 1 Year | — |
Countries
India
Contacts
Public ContactJitendra Rathore
George Clinical
Outcome results
None listed