Effect of administration of the sedative drug, dexmedetomidine, on the pattern of recovery, in patients undergoing neurosurgery under general anesthesia

Effect of intraoperative low dose dexmedetomidine on recovery profiles of sevoflurane and isoflurane based anesthesia for neurosurgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/01/017108

Enrollment

Registered

2019-01-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D332- Benign neoplasm of brain, unspecified Health Condition 2: C719- Malignant neoplasm of brain, unspecified

Interventions

Intervention1: Group SD patients will be given Dexmedetomedine along with titrated Sevoflurane: Inj Dexmedetomedine 0.2 mcg/kg/hour as continuous intravenous infusion and Sevoflurane 1-3% through inha

Eligibility

Inclusion criteria

Inclusion criteria: Patients categorized as American society of Anesthesiology (ASA) class 1 and 2. Age 18-40 years. Glasgow coma scale 15. Patients undergoing surgeries with predicted duration >4 hours, for supratentorial lesions

Exclusion criteria

Exclusion criteria: Patient refusal American society of Anesthesiology (ASA) class III and above Age less than 18 years and more than 40 years Emergency surgery Presence of intracranial vascular abnormalities ( Aneurysm, Arterio venous malformation) Known allergy to Dexmedetomidine or any Î±2 agonists Preoperative heart rate Antihypertensive medication with Î±-methyldopa or Clonidine Patient on beta blockers Presence of Coronary artery disease, Left ventricular dysfunction Pregnant or Nursing woman Participation in another drug study during the preceding 1 month period

Design outcomes

Primary

Measure	Time frame
To compare the recovery profile of patients receiving low dose dexmedetomidine along with volatile anestheticsTimepoint: Time taken (1) to open eyes (2) to obey verbal commands (3) to pass extubation criteria and (4) to get oriented to place and time once maintenance anesthetics are discontinued; RASS and VAS scores at extubation, 30, 60, 90 and 120 minutes after extubation	—

Secondary

Measure	Time frame
Any pain, nausea or vomiting in the post extubation periodTimepoint: Observed for the first 2 hours after extubation;Hemodynamic parameters during the intraoperative periodTimepoint: Every 10 minutes starting from induction; continued till the patient is shifted out of OR	—

Countries

India

Contacts

Public ContactUnnikrishnan P

Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum

drunnikrishnanp@gmail.com9447662321

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026