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COMPARISON DONE TO STUDY THE EFFECT OF TWO DIFFERENT PROCEDURES ON BLOOD STEM CELLS COLLECTED FROM VENOUS BLOOD TO SEE WHETHER REQUIRED DOSE OF STEM CELLS ARE COLLECTED FROM HEALTHY DONORS WHO ARE HAVING ONE OR MORE SUCH FACTORS THAT CAN HAVE NEGATIVE EFFECT ON DOSE COLLECTION

COMPARATIVE STUDY ANALYSING THE IMPACT OF MNC(MONONUCLEAR CELL COLLECTION) AND CMNC(CONTINUOUS MONONUCLEAR CELL COLLECTION) PROTOCOLS ON PBSC(PERIPHERAL BLOOD STEM CELL) FOR DOSE ADEQUACY IN ALLOGENEIC HEMATOPOEITIC STEM CELL TRANSPLANT WITH NEGATIVE COLLECTION PREDICTORS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/01/017103
Enrollment
100
Registered
2019-01-16
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

NO SPONSOR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: LOW PRE CD34+ COUNT LOW PRE COLLECTION PLATELET COUNT FEMALE DONORS WEIGHT DISPARTITY BETWEEN DONOR AND PATIENT(PATIENT WEIGHT >DONOR WEIGHT) DONORS WITH HEMOGLOBIN < 9 gm/dl

Exclusion criteria

Exclusion criteria: Autologous hematopoietic stem cell collections Donors with H/O Cardiac disease or Medical history of ischemia or hemorrhagic stroke in last 6 months Donors with Respiratory insuffiency Donors with Active hepatitis Donors with known hypersensitivity or condition that prevents the use of anticoagulants Concurrent enrollment of the donors in another clinical study that could impact the results or participation in this study Donors with Active infection or any serious underlying medical condition that contraindicates apheresis Women donors who are pregnant or lactating Donors with known history of significant head trauma Donors for whom stem cell would be cryopreserved before transplant in the recipient

Design outcomes

Primary

MeasureTime frame
the primary objective outcome of the study will be the comparison of the following criteria between two said protocols of apheresisTimepoint: Volume of whole blood processed to achieve target dose Time taken to finish the procedure Collection efficiency—

Secondary

MeasureTime frame
Transplantation outcomes will be compared between patients who had received allograft from donor who had undergone stem cell collection with undergoing MNC protocol with patients receiving allograft from donor undergoing stem cell collection with respect toTimepoint: period of engraftment transfusion requirment during the engraftment period—

Countries

India

Contacts

Public ContactDR RAMESH YADAV

BLK SUPER SPECIALITY HOSPITAL

drrasikasetia@blkhospital.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026