A clinical trial to study the effect of two drugs ropivacaine and levobupivacaine in labor pain relief by dural puncture epidural technique

Comparison of analgesic efficacy of ropivacaine and levobupivacaine in labor analgesia by dural puncture epidural technique- A prospective double-blinded randomized trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/01/017099

Enrollment

Registered

2019-01-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Ropivacaine: 20 ml of 0.125% ropivacaine and 2mcg/ml of fentanyl given by dural puncture epidural technique Control Intervention1: Levobupivacaine: 20 ml of 0.125% levobupivacaine and

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I and ASA II parturient having single fetus in vertex presentation 2. Patients in active labor with cervical dilatation 3. Patients desiring labor analgesia

Exclusion criteria

Exclusion criteria: 1. Patients refusal to participate 2. Patients with diseases of pregnancy such as gestational hypertension, preeclampsia, gestational diabetes mellitus 3. Patients in whom neuraxial procedures are contraindicated 4. Patients having fetus with anomalies 5. Patients who are at high chance for cesarean delivery such as cephalopelvic disproportion, previous cesarean section

Design outcomes

Primary

Measure	Time frame
Time of onset to NPRS score â?¤ 1Timepoint: 0.5,2,4,6,8,10,12,14,16,18,20 and 30 minutes, then every 90 minutes until delivery	—

Secondary

Measure	Time frame
1. Symmetry of blockade 2. Maternal adverse effects such as pruritus, hypotension, uterine tachysystole and hypertonus 3. Time to delivery 4. Mode of delivery 5. Fetal outcomes by APGAR 6. Number of boluses by PCEA 7. Number of physician top-up interventionsTimepoint: 0.5,2,4,6,8,10,12,14,16,18,20 and 30 minutes, then every 90 minutes until delivery	—

Countries

India

Contacts

Public ContactDr Kathiravan T

ALL INDIA INSTITUTE OF MEDICAL SCIENCES,NEW DELHI

jyotsna_punj@yahoo.com9810191116

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026