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The need to assess the voice box and voice-changes in patients who are on long term inhaler therapy for specific type of long term lung disease like asthma and its variants

Role of structural laryngeal assessment and analysis of voice profile in moderate to severe asthmatics and Asthma-COPD Overlap (ACO) patients on at-least six months inhaler corticosteroid (mono or combination) therapy - a Case-Control study in a tertiary care hospital in India.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/01/017087
Enrollment
196
Registered
2019-01-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J454- Moderate persistent asthma

Interventions

Intervention1: videostroboscopy and voice assessment in cases: videostroboscopy to look for lesions like vocal cord edema, vocal cord erythema, leukoplakia, candidiasis etc Assess the voice using modi

Sponsors

INSTITUTIONAL SPONSORSHIP
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients more than 18 years of age 2. Patients presenting to Department of Respiratory Medicine with moderate to severe asthma or ACO on continuous inhaler corticosteroid (mono or combination) therapy as cases and similarly diagnosed patients who are yet to be initiated on therapy as controls 3. Patients who give informed and written consent for the study and photography

Exclusion criteria

Exclusion criteria: 1.Patients on systemic sterid therapy or intermittent inhalational corticosteroid therapy 2. Patients with acute exacerbation of asthma or associated some other lung pathology 3. Patients with prior history of laryngeal pathology or surgery 4. Patients with thyroid disorder 5. Patients who are diabetic, retro-viral positive or cancer chemotherapy who are at risk of oppurtunistic infections like candidiasis 6.Pregnant women 7.Patiets with diagnosis of COPD alone

Design outcomes

Primary

MeasureTime frame
Assess the laryngeal structural changes by videostroboscopy and voice profile by modified GRBAS scale in asthmatics and ACO on atleast 6 months of continuous inhalercorticosteroid (mono or combination) therapy and compare it with similarly diagnosed patients who are yet to be initiated on therapyTimepoint: at 6 months or more of inhaler therapy in cases and at 0 months in controls—

Secondary

MeasureTime frame
Does long-term inhaler therapy cause significant structural laryngeal changes and voice changes or is the disease process itself responsible for it?Timepoint: at more than or equal to 6 months of inhaler therapy in cases and at 0 months in controls—

Countries

India

Contacts

Public ContactDr NeethuV Krishnan

Kasturba Medical College, M.A.H.E

kailesh.pujary@manipal.edu9845144015

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026