Health Condition 1: O098- Supervision of other high risk pregnancies
Conditions
Interventions
Intervention1: Doppler waveforms- MCA PI and UA PI: Doppler waveforms using Middle cerebral Artery PI and Umbilical Artery PI will be done before administration of steroids and 24 after administration
Sponsors
Kasturba Hospital Manipal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pregnancies between 28 and 34 weeks of gestation 2. Singleton pregnancies
Exclusion criteria
Exclusion criteria: 1. Period of gestation 30 weeks. 2. Period of gestation 34 weeks. 3. Previous history of receiving antenatal steroids. 4. Multiple gestations. 5. Obvious fetal and uterine anomalies. 6. Contraindications to steroids like systemic infections and peptic ulcer disease. 7. Mothers on drugs like magnesium sulphate and benzodiazepines which alter NST pattern in fetus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in Doppler- Uterine Artery PI and Middle Cerebral Artery PI after antenatal administration of corticosteroids 2. Change in baseline heart rate, beat to beat variability, accelerations, decelerations of NST after antenatal administration of corticosteroids.Timepoint: 1. Before steroid administration (baseline) 2. 24 hours after administration of 1st dose of steroid | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Comparison of change in NST, UA PI and MCA PI in â?? a) AGA fetus b) IUGR fetus 2. Comparison of change in NST, UA PI and MCA PI after administration of- a)Dexamethasone b) Betamethasone Timepoint: 1. Before steroid administration (baseline) 2. 24 hours after administration of 1st dose of steroid | — |
Countries
India
Contacts
Public ContactAnjali M
Manipal Academy of Higher Education
Outcome results
None listed