Health Condition 1: C169- Malignant neoplasm of stomach, unspecified
Conditions
Interventions
Intervention1: Neoadjuvant Chemotherapy: Patients recieve neoadjuvant Chemotherapy followed by surgery
Intervention2: Surgery: Patients go for upfront surgery
Control Intervention1: NA: NA
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Patients attending surgery clinics with TNM stage T3, T4, any N, M0 histologically proven adenocarcinoma stomach by UGI endoscopy guided biopsy and Contrast enhanced CT scan(CECT) will be included in the study
Exclusion criteria
Exclusion criteria: Patients with any other coexisting malignancies, age 70 and above, those who are already on chemotherapy, and patients with recurrence will be not included in the study. Tumors localized to Gastroesophageal junction (Type I) will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| I. To study the down-staging effect of Neoadjuvant Chemotherapy on tumor size, Tumor Node Metastasis (TNM) stage of Locally Advanced Carcinoma Stomach. II. To study R0 resection rates with and without Neoadjuvant Chemotherapy in Locally Advanced Carcinoma Stomach. Timepoint: I. After 3 to 4 cycles of Neoadjuvant chemotherapy, response will be assessed with CECT abdomen. II. R0 resection will be studied on post operative biopsy report. Patient will be taken for surgery after response assessment after 3 to 4 cycles of NACT | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate intraoperative complications and post operative complications with and without Neoadjuvant Chemotherapy in the short term follow up in patients with Locally Advanced Carcinoma Stomach.Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactSOORYABHALA S
JIPMER
Outcome results
None listed