Health Condition 1: R893- Abnormal level of substances chiefly nonmedicinal as to source in specimens from other organs, systems and tissues
Conditions
Interventions
Intervention1: healthy patients: GCF and gingival tissue samples of healthy patients
Control Intervention1: chronic and aggressive periodontitis patients: GCF and gingival tissue samples of chronic an
Sponsors
Dr Shivaprasad BM
Eligibility
Inclusion criteria
Inclusion criteria: 1.Healthy subjects should be systemically healthy and showing absence of clinical manifestations of periodontal disease. 2.Chronic periodontitis patients having at least 20 natural teeth and minimum of six teeth with periodontal pockets >= 5mm and clinical attachment level >= 3-4 mm. 3.Generalised aggressive periodontitis patients with clinical attachment level >= 5mm affecting at least three teeth other than first molars and incisors and moderate to severe bone loss as assessed by radiographs. 4.All the patients should be systemically healthy and should not have received periodontal treatment for at least 6 months prior to the clinical examination and sampling.
Exclusion criteria
Exclusion criteria: 1.Smokers. 2.Systemic diseases like diabetes mellitus, heart diseases, rheumatoid arthritis, hepatitis and other systemic diseases that can alter the course of periodontal disease. 3.Diseases of oral hard and soft tissue except caries and periodontitis. 4.Subjects on any medication taken within the last 6 months which may alter the periodontal status. 5.Pregnant and lactating mothers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| levels of interferon lambdas expression in gingival crevicular fluid and gingival tissue samples of chronic and aggressive periodontitis patients and to correlate with herpes virusesTimepoint: levels of interferon lambdas expression in gingival crevicular fluid and gingival tissue samples of chronic and aggressive periodontitis patients and to correlate with herpes viruses assessed immediately after collection at baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Gingival index clinical attachment level probing pocket depth of chronic and aggressive periodontitis patientsTimepoint: Gingival index clinical attachment level probing pocket depth of chronic and aggressive periodontitis patients assessed at the time of baseline | — |
Countries
India
Contacts
Public ContactDr Shivaprasad BM
Rajarajeswari Dental College and hospital
Outcome results
None listed